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Prolozone or Prolotherapy

Prolotherapy is an injection therapy for treatment of pain and tendon/ligament injury. The concept of prolotherapy involves strengthening the ligaments and tendons of the body by injection of a proliferative agent, thus the name prolo-therapy.

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Nerves run within the ligaments and tendons and can be stretched if they are weak. Muscles must work overtime to compensate for loose ligaments. Pain is caused by stretching of the nerves and by the muscular strain. Strengthening the ligaments and tendons can help to alleviate the pain due to less nerve irritation and alleviating the stress on the muscles.

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Any ligament that has been injured will recover only 70% of its prior strength without treatment such as prolotherapy.

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Prolotherapy involves injection of dextrose to the insertion of ligaments which is like dropping a chemical beacon allowing the surrounding cells to leak growth factors. As time goes by, growth factors attract the fibroblasts/osteoblasts and these cells make more connective tissue so that ligaments and tendons become stronger.

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Joint pain, as is seen in arthritis, also involves the loss of strength of connective tissue which surrounds the joint. The original injury is often due to an unstable joint which causes wear and tear of the joint surfaces and the degenerative process begins and pain results. Prolotherapy addresses the cause of the pain and stabilizes the joint. After an average to 3 to 6 treatments the ligament may start to support the way it was meant to. Tenderness may be felt for 2 days to 2 weeks following prolotherapy as inflammation may be triggered to induce a wound-healing cascade.

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Prolozone: Prolozone therapy adds the use of ozone gas to the injection therapy. Ozone gas further stimulates chondroblasts to produce more connective tissue for the joint. The joint not only has pain reduction but begins to repair. Prolozone therapy causes less tenderness and patients may be sore for 1 to 2 days following injection.


Prolotherapy and/or Prolozone may be an effective treatment for the following conditions:

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  •  Upper and lower back pain

  •  Arthritis

  •  Avoiding hip or knee replacement surgery

  •  Loose joints

  •  Frozen shoulder

  •  Damaged knee ligaments

  •  Sciatica

  •  Pain of the foot, plantar fasciitis

  •  Tennis elbow

  •  Sprained wrist

  •  Chronic ankle sprain

  •  Temporomandibular joint disorder (TMJ)

  •  Lumbar disc herniation

  •  Rotator cuff injuries

  •  Fibromyalgia

  •  Sports injuries

  •  Neck pain

  •  Tendonitis and more

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